The objective of this article is to review the systems based on site specific drug delivery to colon and its recent approaches. The eagerness to develop dosage form which is free from harmful side effects leads to development of site specific drug delivery system that should have additional advantages such as low dose thus reducing the cost of treatment with lower systemic side effects. The Colon targeted Drug Delivery System has recently gained importance in addressing specific needs in the therapy of colonic diseases and highly desirable for local treatment of a various bowel diseases (such as ulcerative colitis, crohn’s disease, amoebiosis, colonic cancer) and systemic delivery of protein and peptide drugs. Various oral approaches for colon targeted delivery of drugs may be categorized as ph dependent (delayed) release, time controlled, pressure controlled and microbial triggered system (i.e. prodrug and polysaccharides). Most recent approach in this field are ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy) and hydrogels (enzymaticaly degradable gels).
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